Tag: pcdna4/to
Synthesis and Characterization of Conducting PANDB/χ-Al 2 O 3 Core-Shell Nanocomposites by In Situ Polymerization
Polyaniline doped with dodecylbenzenesulfonic acid/χ-aluminum oxide (PANDB/χ-Al2O3) conducting core-shell nanocomposites was synthesized by way of an in situ polymerization technique on this research. PANDB was synthesized within the presence of dodecylbenzenesulfonic acid (DBSA), which functioned as a dopant and surfactant. {The electrical} conductivity of the conducting PANDB/χ-Al2O3 core-shell nanocomposite was roughly 1.7 × 10-1 S/cm when the…
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Design, synthesis and biological evaluation of novel acridine and quinoline derivatives as tubulin polymerization inhibitors with anticancer activities
A sequence of acridine and quinoline derivatives had been designed and synthesized primarily based on our earlier work as novel tubulin inhibitors concentrating on the colchicine binding web site. Amongst them, compound 3b exhibited the best antiproliferative exercise with an IC50 of 261 nM towards HepG-2 cells (probably the most delicate cell line). As well as,…
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Intramitochondrial Disulfide Polymerization Controls Cancer Cell Fate
Current advances in supramolecular chemistry analysis have led to the event of synthetic chemical programs that may type self-assembled buildings that imitate proteins concerned within the regulation of mobile perform. Nevertheless, intracellular polymerization programs that function inside residing cells have been seldom reported. On this research, we developed an intramitochondrial polymerization-induced self-assembly system for regulating…
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