micchem

Expanding the Scope of Polymerization-Induced Self-Assembly: Recent Advances and New Horizons

Over the previous decade or so, polymerization-induced self-assembly (PISA) has develop into a flexible methodology for rational preparation of concentrated block copolymer nanoparticles with a various set of morphologies. A lot of the PISA literature has centered on the preparation of well-defined linear block copolymers by utilizing linear macromolecular chain switch brokers (macro-CTAs) with excessive…

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Molecular Recognition of the HPLC Whelk-O1 Selector towards the Conformational Enantiomers of Nevirapine and Oxcarbazepine

Molecular Recognition of the HPLC Whelk-O1 Selector towards the Conformational Enantiomers of Nevirapine and Oxcarbazepine

The presence of stereogenic parts is a standard characteristic in pharmaceutical compounds, and affording optically pure stereoisomers is a frequent difficulty in drug design. On this context, the examine of the chiral molecular recognition mechanism essentially helps the understanding and optimization of chromatographic separations with chiral stationary phases. We investigated, with molecular docking, the interactions…

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