micchem

Superfast and Water-Insensitive Polymerization on α-Amino Acid N-Carboxyanhydrides to Prepare Polypeptides using Tetraalkylammonium carboxylates as the Initiator

Proteins and peptides have numerous organic features and purposes, nonetheless, their environment friendly chemical synthesis continues to be difficult. We design the tetraalkylammonium carboxylate-initiated superfast polymerization on α-amino acid N -carboxyanhydrides (NCA) for environment friendly synthesis of polypeptides. Carboxylates, as a brand new class of initiator for NCA polymerization, can provoke the superfast NCA polymerization with out the necessity of additional catalyst and the polymerization will be operated in open vessels at ambient situation with out using glove field.
Tetraalkylammonium carboxylate-initiated polymerization on NCA simply affords block copolymers with at the least 15 blocks. Furthermore, this technique avoids tedious purification steps and permits direct polymerization on crude NCAs in aqueous environments to organize polypeptides and one-pot synthesis of polypeptide nanoparticles. These benefits and the delicate polymerization situation of tetraalkylammonium carboxylate-initiated NCA polymerization suggest its nice potential in purposeful exploration and utility of polypeptides.

Design, synthesis and bioevaluation of 6-aryl-1-(3,4,5-trimethoxyphenyl)-1H-benzo[d]imidazoles as tubulin polymerization inhibitors

 

A sequence of recent 6-aryl-1-(3,4,5-trimethoxyphenyl)-1H-benzo[d]imidazoles as tubulin polymerization inhibitors concentrating on the colchicine-binding web site have been designed to limit bioactive configuration of (Z,E)-vinylogous CA-4. The entire goal compounds have been synthesized after which evaluated for his or her in vitro antiproliferative actions. Amongst them, 2a exhibited probably the most potent actions in opposition to three most cancers cell traces with IC50 values within the vary of 0.037-0.20 μM.
Additional mechanism research revealed that 2a inhibited tubulin polymerization, disrupted cell microtubule networks, arrested the cell cycle at G2/M part, induced apoptosis and hindered most cancers cell migration. Furthermore, 2a displayed important in vivo antitumor efficacy in 4T1-xenograft mice mannequin with tumor development inhibition fee of 52% on the dose of two.5 mg/kg. Colchicine competitors assay and the docking mannequin of 2a in complicated with tubulin confirmed that 2a acted on the colchicine-binding web site.
Gamma-irradiation initiated polymerization was utilized to organize polyacrylic acid dolomite P(AA/D) nanocomposites. Completely different analytical strategies have been utilized to analyze the construction of the brand new supplies. XRD and TEM revealed the crystalline part with a median particle dimension starting from 2 to Four nm. The power of the ready supplies to take away cesium, cobalt, and zirconium ions from aqueous options was evaluated.
The adsorption capability of studied nanocomposites has an affinity sequence; Zr4+>Co2+≫Cs+ with values 77.8, 72.4, and 34.9 mg/g respectively. The impact of the interfering species reveals that the fee of adsorption of cesium, cobalt, and zirconium ions decreases with growing concentrations of the interfering species. The investigation proved that the ready nanocomposite is appropriate materials for the elimination of the studied metals from aqueous options and could possibly be thought of as potential materials for purification of effluent polluted with these metallic ions.

Modified Graphene Oxide-Included Skinny-Movie Composite Hole Fiber Membranes via Interface Polymerization on Hydrophilic Substrate for CO 2 Separation

Skinny-film composite blended matrix membranes (CMMMs) have been fabricated utilizing interfacial polymerization to attain excessive permeance and selectivity for CO2 separation. This examine revealed the function of substrate properties on efficiency, which aren’t sometimes thought of essential. To be able to improve the affinity between the substrate and the coating answer throughout interfacial polymerization and improve the selectivity of CO2, a mix of polyethylene glycol (PEG) and dopamine (DOPA) was subjected to a spinning course of.
Then, the floor of the substrate was subjected to interfacial polymerization utilizing polyethyleneimine (PEI), trimesoyl chloride (TMC), and sodium dodecyl sulfate (SDS). The impact of including SDS as a surfactant on the construction and gasoline permeation properties of the fabricated membranes was examined. Skinny-film composite hole fiber membranes containing modified graphene oxide (mGO) have been fabricated, and their traits have been analyzed. The membranes exhibited very promising separation efficiency, with CO2 permeance of 73 GPU and CO2/N2 selectivity of 60. From the design of a membrane substrate for separating CO2, the CMMMs hole fiber membrane was optimized utilizing the lively layer and mGO nanoparticles via interfacial polymerization.

Synthesis of branched β-1,3-glucan oligosaccharide with slim diploma of polymerization by fungi co-cultivation

The big molecular weight and poor water solubility of β-1,3-glucan impede its potential purposes. On this examine, the β-1,3-glucan producing fungi and Trichoderma harzianum able to secreting endo-β-1,3-glucanase have been co-cultivated to provide branched β-1,3-glucan oligosaccharides (bOβGs) by fermentation with Sclerotium rolfsii and Schizophyllum commune.
The very best bOβG yields from S. rolfsii in flasks have been 4.53 and 9.94 g/L in a 7 L fermenter. Structural evaluation proved that bOβG from S. rolfsii had a slim diploma of polymerization of 5-12, whereas bOβG from S. commune had a level of polymerization of 5-15. Antioxidant assessments confirmed that each bOβGs had exceptional DPPH radical scavenging exercise and hydroxyl radical scavenging exercise, and the exercise of bOβG from S. commune was higher than that of bOβG from S. rolfsii. As well as, bOβGs might promote the secretion of NO by mouse macrophages and improve the manufacturing of TNF-α, IL-1β, and IL-6 in RAW264.7.
micchem
micchem

Cellulose nanocrystals focus and oil-water ratio for solid-liquid controllable emulsion polymerization

Stabilities of cellulose Pickering emulsions are of nice significance to make the most of them successfully, however influenced by their complicated compositions, equivalent to, colloidal particles, oil phases and water phases. On this work, solid-liquid controllable polymerization merchandise might acquire by adjusting cellulose nanocrystals (CNCs) focus and vinyl acetate (VAc)-water ratio.
The emulsions in zone Ӏ (w/o) and II (o/w) of the three-phase diagram have been chosen for researching. The polymerization emulsions in zone II illustrated the o/w ratio performed a extra essential function than CNCs focus within the storage stability and practicality of the polymerized emulsion; The polymer in zone Ӏ confirmed a lot of porous constructions. That is an progressive technique that completely different types of goal merchandise are obtained via the steerage of three-phase diagram, which not solely broadens the applying subject, but in addition applies to different Pickering emulsion methods.
Tungsten disulfide nanotubes (WS2-NTs) have been discovered to be very lively for photothermal remedy. Nevertheless, their lack of stability in aqueous options inhibits their use in lots of purposes, particularly in biomedicine. Few makes an attempt have been made to chemically functionalize the floor of the NTs to enhance their dispersability. Right here, we current a brand new polymerization technique utilizing cerium-doped maghemite nanoparticles (CM-NPs) as magnetic nanosized linkers between the WS2-NT floor and pyrrole-N-propionic acid monomers, which permit in situ polymerization onto the composite floor. This distinctive composite is magnetic, and incorporates two lively entities for photothermal therapy-WS2 and the polypyrrole. The photothermal exercise of the composite was examined at a wavelength of 808 nm, and important thermal exercise was noticed. Furthermore, the polycarboxylated polymeric coating of the NTs permits efficient linkage of extra molecules or medicine through covalent bonding. As well as, a brand new technique was established for large-scale synthesis of CM-NPs and WS2-NT-CM composites.

mIgG TRF 200

MIGTR1012-200 1 Kit
EUR 347

ODN 2007-Type B bovine/porcineTLR9 agonist-antigen grade, 200 ug

ODN2007-200 200 ug Ask for price

Pico488 dsDNA quantification kit, 200

1102-200 200 assays
EUR 290

FA-PEG-COOH,200

HE057017-200-100mg 100mg
EUR 520
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

DiagNano Streptavidin Conjugated Gold Nanoparticles, 200 nm

GCS-200 1mL
EUR 1084

InstantAgarose?, Agarose Tablet, 0.5g, 200 tabs, blister convenient pack

R9012TAB-200
EUR 163

Polyethylene Glycol (PEG)

abx085411-335kDa55kg 3.35 kDa; 5.5 kg
EUR 244
  • Shipped within 5-10 working days.

Polyethylene glycol 4000

GX6931-100G 100 g
EUR 44

Polyethylene glycol 4000

GX6931-1KG 1 kg
EUR 62

Polyethylene glycol 4000

GX6931-500G 500 g
EUR 49

Polyethylene glycol 1000

GC0081-100G 100 g
EUR 46

Polyethylene glycol 8000

GC0902-100G 100 g
EUR 48

Polyethylene glycol 8000

GC0902-1KG 1 kg
EUR 77

Polyethylene glycol 8000

GC0902-500G 500 g
EUR 62

Polyethylene glycol 6000

GC2342-100G 100 g
EUR 44

Polyethylene glycol 6000

GC2342-1KG 1 kg
EUR 62

Polyethylene glycol 6000

GC2342-500G 500 g
EUR 49

Polyethylene glycol 400

GC3481-100G 100 g
EUR 41

Polyethylene glycol 400

GC3481-1KG 1 kg
EUR 65

Polyethylene glycol 400

GC3481-250G 250 g
EUR 46

Polyethylene glycol 400

GC3481-500G 500 g
EUR 53

Polyethylene glycol 400

GC3481-5KG 5 kg
EUR 153

Polyethylene glycol 300

GC9998-100G 100 g
EUR 40

Polyethylene glycol 300

GC9998-1KG 1 kg
EUR 62

Polyethylene glycol 300

GC9998-250G 250 g
EUR 44

Polyethylene glycol 300

GC9998-500G 500 g
EUR 52

Polyethylene glycol 300

GC9998-5KG 5 kg
EUR 142

Polyethylene glycol 1500

GK2627-100G 100 g
EUR 44

Polyethylene glycol 1500

GK2627-1KG 1 kg
EUR 62

Polyethylene glycol 1500

GK2627-500G 500 g
EUR 49

Anti-Human Ephrin Type A receptor 2 (1C1), Human IgG1 Antibody

A1095-200
EUR 729

Polyethylene Glycol (PEG) Antibody

abx021053-100ug 100 ug
EUR 871
  • Shipped within 5-10 working days.

Polyethylene Glycol (PEG) Antibody

abx021054-100ug 100 ug
EUR 871
  • Shipped within 5-10 working days.

Polyethylene Glycol (PEG) Antibody

20-abx132170
  • EUR 439.00
  • EUR 133.00
  • EUR 1261.00
  • EUR 606.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

PEG 4000 (Polyethylene glycol)

PB0431 500g
EUR 63.05
  • Product category: Biochemicals/Biology Reagents/Other

PEG 6000 (Polyethylene glycol)

PB0432 500g
EUR 63.05
  • Product category: Biochemicals/Biology Reagents/Other

PEG 8000 (Polyethylene glycol)

PB0433 500g
EUR 63.05
  • Product category: Biochemicals/Biology Reagents/Other

TNFR2 Tumor Necrosis Factor Receptor Type 2 Human Recombinant Protein

PROTP20333-2 Regular: 20ug
EUR 317
Description: TNFR2 Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 184 amino acids and having a molecular mass of 20kDa. The TNFR2 is purified by proprietary chromatographic techniques.

Polyethylene Glycol (PEG) Antibody (Biotin)

abx021052-005mg 0.05 mg
EUR 815
  • Shipped within 5-10 working days.

Polyethylene Glycol (PEG) ELISA Kit

20-abx258764
  • EUR 7973.00
  • EUR 4246.00
  • EUR 981.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests
  • Shipped within 5-7 working days.

BSA Conjugated Polyethylene Glycol (PEG)

4-CPX163Ge11
  • EUR 413.60
  • EUR 214.00
  • EUR 1276.00
  • EUR 492.00
  • EUR 884.00
  • EUR 340.00
  • EUR 3040.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: Inquire
  • Buffer composition: PBS, pH 7.4.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 62.1Da
  • Isoelectric Point: Inquire
Description: Recombinant Pan-species Polyethylene Glycol expressed in: E.coli

OVA Conjugated Polyethylene Glycol (PEG)

4-CPX163Ge21
  • EUR 413.60
  • EUR 214.00
  • EUR 1276.00
  • EUR 492.00
  • EUR 884.00
  • EUR 340.00
  • EUR 3040.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: Inquire
  • Buffer composition: PBS, pH 7.4.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 62.1Da
  • Isoelectric Point: Inquire
Description: Recombinant Pan-species Polyethylene Glycol expressed in: E.coli

Polyethylene Glycol (PEG) Protein (BSA)

20-abx651925
  • EUR 578.00
  • EUR 258.00
  • EUR 1720.00
  • EUR 690.00
  • EUR 425.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Polyethylene Glycol (PEG) Protein (OVA)

20-abx651926
  • EUR 578.00
  • EUR 258.00
  • EUR 1720.00
  • EUR 690.00
  • EUR 425.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Polyethylene Glycol (PEG) CLIA Kit

20-abx490560
  • EUR 9242.00
  • EUR 4920.00
  • EUR 1130.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests
  • Please enquire.

AXYGEN® AXYPET® PRO 20-200 ΜL SINGLE-CHANNEL PIPETTOR, AUTOCLAVABLE

AP-200-P 1/pk
EUR 202
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

TruStrip Sample Transfer Strips, 200-ul, 50/Pk (without sample tracking dye)

STS-200-50 1 Pk Ask for price

TruStrip Sample Transfer Strips, 200-ul, 50/Pk (with sample tracking dye)

STSD-200-50 1 Pk Ask for price

Human Anti-Mouse IgG (HAMA) positive control (for use with #200-205-HAM)

200-208-C1 1 ml
EUR 225

General Polyethylene Glycol (PEG) ELISA Kit

CEX163Ge-10x96wellstestplate 10x96-wells test plate
EUR 6040.5
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of General Polyethylene Glycol (PEG) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-Assay: CV<12%
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of General Polyethylene Glycol (PEG) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

General Polyethylene Glycol (PEG) ELISA Kit

CEX163Ge-1x48wellstestplate 1x48-wells test plate
EUR 585.1
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of General Polyethylene Glycol (PEG) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-Assay: CV<12%
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of General Polyethylene Glycol (PEG) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

General Polyethylene Glycol (PEG) ELISA Kit

CEX163Ge-1x96wellstestplate 1x96-wells test plate
EUR 793
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of General Polyethylene Glycol (PEG) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-Assay: CV<12%
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of General Polyethylene Glycol (PEG) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

General Polyethylene Glycol (PEG) ELISA Kit

CEX163Ge-5x96wellstestplate 5x96-wells test plate
EUR 3268.5
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of General Polyethylene Glycol (PEG) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-Assay: CV<12%
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of General Polyethylene Glycol (PEG) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

General Polyethylene Glycol (PEG) ELISA Kit

4-CEX163Ge
  • EUR 6091.00
  • EUR 3219.00
  • EUR 794.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
  • Known also as Polyethylene Glycol elisa. Alternative names of the recognized antigen: PEO
  • POE
  • Polyethylene oxide
  • Polyoxyethylene
  • Carbowax
  • GoLYTELY
  • GlycoLax
  • Fortrans
  • TriLyte
  • Colyte
  • Halflytely
  • Macrogol
  • MiraLAX
  • MoviPrep
Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of General Polyethylene Glycol (PEG) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.

D-alpha-Tocopherol polyethylene glycol succinate

GK2339-25G 25 g
EUR 150

D-alpha-Tocopherol polyethylene glycol succinate

GK2339-5G 5 g
EUR 70

General Polyethylene Glycol ELISA Kit (PEG)

RK00701 96 Tests
EUR 573

HSV type 1 Glycoprotein G (aa 34 - 200) [His]

DAG2013 100 µg
EUR 913

ODN 2216-Type A human TLR9 Agonist.-antigen grade, 200ug

ODN2216-200 200 ug
EUR 347

AXYGEN® AXYPET® PRO 20-200 ΜL, 12 CHANNEL PIPETTOR, AUTOCLAVABLE

AP-12-200-P 1/pk
EUR 484
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

AXYGEN® AXYPET® PRO 20-200 ΜL, 8 CHANNEL PIPETTOR, AUTOCLAVABLE

AP-8-200-P 1/pk
EUR 455
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

Torin 2

B1640-200 200 mg
EUR 1031
Description: Torin2 is a potent, selective and orally available inhibitor of mTOR with EC50 value of 0.25nM [1].Torin2 is a highly potent and selective mTOR inhibitor.

MI-2

A3602-200 200 mg
EUR 1558
Description: MI-2 is a Menin-MLL inhibitor with IC50 value of 0.45 ?M [1]. Mixed-lineage leukemia (MLL) is a common target of chromosomal translocations in patients with acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).

High Sensitivity Polyethylene Glycol (PEG) ELISA Kit

DEIA6158 96T
EUR 1165
Description: High Sensitivity Polyethylene Glycol (PEG) ELISA Kit is High Sensitivity ELISA for the Measurement of PEG and PEGylated Proteins.

ELISA kit for General PEG (Polyethylene Glycol)

ELK8264 1 plate of 96 wells
EUR 372
  • A monoclonal antibody specific to Polyethylene Glycol (PEG) has been pre-coated onto a microplate. A competitive inhibition reaction is launched between biotin labeled Polyethylene Glycol (PEG) and unlabeled Polyethylene Glycol (PEG) (Standards or sa
  • Show more
Description: A competitive Inhibition ELISA kit for detection of Polyethylene Glycol from General in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Polyethylene Glycol (PEG) Polyclonal Antibody (Pan-species)

4-PAX163Ge01
  • EUR 253.00
  • EUR 2615.00
  • EUR 649.00
  • EUR 319.00
  • EUR 217.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Inquire for antigen sequence.
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Pan-species Polyethylene Glycol (PEG)

Disposable Polyethylene Gloves Pe, Large, 100/Box

GL011L 1PK, 100UNIT
EUR 53.32
  • Product category: Labware/Lab Safety Equipment/Gloves

Disposable Polyethylene Gloves Pe, Medium, 100/Box

GL011M 1PK, 100UNIT
EUR 53.32
  • Product category: Labware/Lab Safety Equipment/Gloves

Disposable Polyethylene Gloves Pe, Small, 100/Box

GL011S 1PK, 100UNIT
EUR 53.32
  • Product category: Labware/Lab Safety Equipment/Gloves

Relaxin-2 Antibody

3903-200
EUR 316

pGL3-Basic-PD-L1 promoter(-200~+200) Plasmid

PVTB00385-2e 2 ug
EUR 356

Cellufine A-200

676-980-327 100 ml
EUR 324

Cellufine A-200

676980335 10 lt Ask for price

Cellufine A-200

19611 500 ml
EUR 526

Cellufine A-200

19612 5 lt Ask for price

Anti-MMP23 (200)

YF-MA16389 100 ug
EUR 363
Description: Mouse monoclonal to MMP23

BNP Human, B-type Natriuretic Peptide Human Recombinant Protein, His Tag

PROTP16860-2 Regular: 10ug
EUR 317
Description: BNP Recombinant Human fused with 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 129 amino acids (27-134 a.a) and having a molecular mass of 14 kDa.                   

2-Propyl-β-D-glucuronide, 2 mg

0904-2 2 mg
EUR 162

Caspase-2 Substrate VDVAD-AFC

1071-200
EUR 327

Caspase-2 Substrate VDVAD-pNA

1072-200
EUR 338

Caspase-2 Fluorometric Assay Kit

K2016-200 200 assays
EUR 696

Caspase-2 Colorimetric Assay Kit

K2017-200 200 assays
EUR 725

Caspase-2 Fluorometric Assay Kit

K116-200
EUR 615

Caspase-2 Colorimetric Assay Kit

K117-200
EUR 615

Cyclooxygenase 2, Human Recombinant (Insect)

P1344-200
EUR 153

Self-Sealing Sterilization Pouches, 31/2 x 61/2 ( 8.9 x 16.5 cm)

LC3043-200 200/bx
EUR 70

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