Author: Zachary Long
HPLC Determination of Imidazoles with Variant Anti-Infective Activity in Their Dosage Forms and Human Plasma
An appropriate HPLC technique has been chosen and validated for speedy simultaneous separation and dedication of 4 imidazole anti-infective medication, secnidazole, omeprazole, albendazole, and fenbendazole, of their closing dosage types, along with human plasma inside 5 min. The tactic suitability was derived from the prevalence of utilizing the environmentally benign solvent, methanol over acetonitrile as…
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Spinochrome Identification and Quantification in Pacific Sea Urchin Shells, Coelomic Fluid and Eggs Using HPLC-DAD-MS
The high-performance liquid chromatography technique coupled with diode array and mass spectrometric detector (HPLC-DAD-MS) technique for quinonoid pigment identification and quantification in sea urchin samples was developed and validated. The composition and quantitative ratio of the quinonoid pigments of the shells of 16 species of sea urchins, collected within the temperate (Sea of Japan) and…
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Single-run reversed-phase HPLC method for determining sertraline content, enantiomeric purity, and related substances in drug substance and finished product
A direct enantio-, diastereo-, and chemo-selective high-performance liquid chromatographic methodology was developed for figuring out the content material, enantiomeric purity, and associated substances of the chiral antidepressant drug sertraline HCl in a single chromatographic run. The separation was achieved on a chiral stationary part based mostly on amylose tris(3-chloro-5-methylphenylcarbamate) beneath reversed-phase circumstances. The strategy was…
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HPLC-DAD-MS and Antioxidant Profile of Fractions from Amontillado Sherry Wine Obtained Using High-Speed Counter-Current Chromatography
Within the current work, the polyphenolic profile of a posh matrix equivalent to Amontillado sherry has been processed via high-speed counter-current chromatography (HSCCC) and characterised by HPLC-DAD-MS. An Amberlite XAD-7 column was used to acquire the wine extract, and three totally different biphasic solvent methods had been utilized for HSCCC separation: MTBE (methyl tert-butyl ether)/n-butanol/acetonitrile/water (1.1/3/1.1/5+0.1%…
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